Hypofibrinogenemia is associated with a high degree of risk in infectious diseases: a post-hoc analysis of post-marketing surveillance of patients with disseminated intravascular coagulation treated with thrombomodulin alfa

Abstract Background In patients with infectious diseases, disseminated intravascular coagulation (DIC) is often diagnosed without the fibrinogen value. The relationship between hypofibrinogenemia and outcomes of DIC in diseases has thus remained unclear. Methods We analyzed 3204 who received thrombomodulin alfa (TM-?) for suspected DIC. Hypofibrinogenemia was defined by a level < 1.5 g/L. Results observed 10.3% diseases. frequencies both bleeding organ failure symptoms, scores or diagnostic criteria were significantly higher disease hypofibrinogenemia, suggesting that associated more progressive severe Although 28-day survival rate resolution lower than those this difference not hematological Conclusions among may reflect increased consumption due to accelerated reactions, while be caused fibrinogenolysis hyperfibrinolysis, frequently results multiple-organ failure.